General information CEG ID: CEG0131 Function: dihydrofolate reductase Phyletic Profile: Genes in 16 /29 species: single-copy in16 species and multi-copy in 0 species. In Genus: 13 /20 in GenusShewanella,Vibrio,Staphylococcus,Acinetobacter,Mycobacterium,Haemophilus,Bacillus,Streptococcus,Mycoplasma,Pseudomonas,Francisella,Salmonella,EscherichiaIn Family: 12 /18 in FamilyBacillaceae,Streptococcaceae,Francisellaceae,Enterobacteriaceae,Moraxellaceae,Mycoplasmataceae,Shewanellaceae,Pasteurellaceae,Vibrionaceae,Mycobacteriaceae,Pseudomonadaceae,StaphylococcaceaeIn Order: 10 /16 in OrderLactobacillales,Thiotrichales,Vibrionales,Actinomycetales,Pasteurellales,Enterobacteriales,Alteromonadales,Bacillales,Mycoplasmatales,PseudomonadalesIn Class: 4 /9 in ClassActinobacteria,Mollicutes,Gammaproteobacteria,BacilliIn Phylum: 4 /5 in PhylumTenericutes,Firmicutes,Proteobacteria,Actinobacteria
CEG_gene ID Gene name(s) Function Pathway Struct Drug ESAHP Organism DEG ID Virulence Protein-Ligand CEG0131 _ 16079240 dfrA dihydrofolate reductase See pathway bsu00790+BSU21810 bsu00670+BSU21810 See drug DB08234 9.9e-017 bsu DEG10010151 CEG0131 _ 15927007 dfrA dihydrofolate reductase See pathway sau00790+SA1259 sau00670+SA1259 See drug DB08234 5.3e-007 spu DEG10020156 CEG0131 _ 15640467 VC0440 dihydrofolate reductase 2.4e-012 vch DEG10030078 CEG0131 _ 16272837 folA dihydrofolate reductase See pathway hin00790+HI0899 hin00670+HI0899 See drug DB02809 DB03125 DB00951 DB04007 DB02015 DB02363 DB02718 DB03461 DB03625 DB03904 DB07262 DB07938 DB08234 DB08741 5.6e-012 hin DEG10050323 CEG0131 _ 12045083 dhfR dihydrofolate reductase 1.0e-005 mtu DEG10060193 CEG0131 _ 15903472 dfr Dihydrofolate reductase 0.026 stm DEG10070193 CEG0131 _ 118496839 folA dihydrofolate reductase type I See pathway ftn00790+FTN_0226 ftn00670+FTN_0226 See drug DB02809 DB03125 DB00951 DB04007 DB02015 DB02363 DB02718 DB03461 DB03625 DB03904 DB07262 DB07938 DB08234 DB08741 3.1e-012 ftn DEG10120040 CEG0131 _ 50083752 folA dihydrofolate reductase See pathway aci00790+ACIAD0514 aci00670+ACIAD0514 See drug DB02809 DB03125 DB00951 DB04007 DB02015 DB02363 DB02718 DB03461 DB03625 DB03904 DB07262 DB07938 DB08234 DB08741 2.8e-011 aci DEG10130087 CEG0131 _ 15829008 dhfr Dihydrofolate reductase 0.013 mge DEG10140203 CEG0131 _ 116054078 folA dihydrofolate reductase See pathway pau00790+PA14_04580 pau00670+PA14_04580 See drug DB02809 DB03125 DB00951 DB04007 DB02015 DB02363 DB02718 DB03461 DB03625 DB03904 DB07262 DB07938 DB08234 DB08741 9.1e-021 pau DEG10150012 CEG0131 _ 88195158 SAOUHSC_01434 dihydrofolate reductase 5.3e-007 stt DEG10170184 CEG0131 _ 16128042 folA Dihydrofolate reductase (EC 1.5.1.3) See pathway eco00790+b0048 eco00670+b0048 See struct 1DDR 1DDS 1DHI 1DHJ 1DRA 1DRB 1DRE 1DRH 1DYH 1DYI 1DYJ 1JOL 1JOM 1RA1 1RA2 1RA3 1RA8 1RA9 1RB2 1RB3 1RC4 1RD7 1RE7 1RF7 1RG7 1RH3 1RX1 1RX2 1RX3 1RX4 1RX5 1RX6 1RX7 1RX8 1RX9 1TDR 2ANO 2ANQ 2D0K 2DRC 2INQ 3DAU 3DRC 3K74 3KFY 3OCH 3QL3 3QYL 3QYO 3R33 4DFR See drug DB02809 DB03125 DB00951 DB04007 DB02015 DB02363 DB02718 DB03461 DB03625 DB03904 DB07262 DB07938 DB08234 DB08741 3.1e-009 eco DEG10190005 See receptor_ligand 0008030 0008031 0008032 0008033 0008034 0008035 0008036 0008304 0008305 0008306 0008307 0009025 0009026 0009027 0009028 0009029 0009030 0009034 0009580 0009581 0009582 0009583 0009584 0009585 0009586 0026546 0026547 0026548 0026549 0026550 0049697 0049698 0049699 0049700 0049701 0049702 0049706 0049707 0049708 0049762 0049763 0049764 0049765 0049766 0049767 0049768 0049769 0049840 0049841 0049922 0049923 0050037 0050038 0050101 0050102 0050190 0050283 0050284 0051696 0051697 0051698 0051699 0051700 0051701 0051702 0051703 0051704 0051705 0051706 0051707 0051708 0051709 0055977 0055978 0055979 0055980 0055981 0055982 0076438 0076439 0076442 0076443 0083412 0083413 0084986 0084987 0097598 0097599 0147890 0147891 0149290 0149291 0172158 0172159 0172160 0187050 0187051 0187052 0196861 0196862 0198207 0198208 0198209 0198235 0198236 0198237 0198529 0198530 0198531 0198532 0198533 0198534 0198535 0198536 0198537 0198538 0198539 0198540 0198541 0198542 0224332 0224333 CEG0131 _ 125717922 dfrA dihydrofolate reductase See pathway ssa00790+SSA_1092 ssa00670+SSA_1092 See drug DB08234 3.7e-004 ssa DEG10210110 CEG0131 _ 15609900 dfrA Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) See struct 1DF7 1DG5 1DG7 1DG8 2CIG 4KL9 4KLX 4KM0 4KM2 4KNE 4M2X See drug DB08234 3.2e-011 mpu DEG10250537 See receptor_ligand 0008135 0008136 0008137 0008138 0008139 0008140 0008208 0008209 0008210 0008211 0008212 0008213 0008214 0008215 0008216 0008217 0008218 0008219 0008220 0008221 0082351 0265561 0265562 0265563 0265564 0265565 0265566 0265567 0265568 0265569 0265570 0265571 0265572 0265573 0265574 0265575 0299058 0299059 0299060 0299061 0299062 0299063 0299064 0299065 CEG0131 _ 24375145 folA dihydrofolate reductase FolA See pathway son00790+SO_3646 son00670+SO_3646 See drug DB02809 DB03125 DB00951 DB04007 DB02015 DB02363 DB02718 DB03461 DB03625 DB03904 DB07262 DB07938 DB08234 DB08741 6.6e-013 som DEG10290317 CEG0131 _ 378698068 folA dihydrofolate reductase type I See pathway sey00790+SL1344_0088 sey00670+SL1344_0088 See drug DB02809 DB03125 DB00951 DB04007 DB02015 DB02363 DB02718 DB03461 DB03625 DB03904 DB07262 DB07938 DB08234 DB08741 8.2e-009 set DEG10320009