| Information | |
| Gene name: | TOP2 |
| Databases ID: | DEG :DEG20010853 OrthoDB:EOG0937011E UniProt:- |
| Organism: | Saccharomyces cerevisiae |
| Function: | Essential type II topoisomerase, relieves torsional strain in DNA by cleaving and re-sealing the phosphodiester backbone of both positively and negatively supercoiled DNA; cleaves complementary strands; localizes to axial cores in meiosis |
| Nucleotide sequence: | Length=4287bp |
| BlastN NCBI nr
BlastX NCBI nr
BlastN NCBI Human
ATGTCAACTGAACCGGTAAGCGCCTCTGATAAATATCAGAAAATTTCTCAACTGGAACATATCTTAAAAAGACCAGACACTTATATCGGTTCTGTTGAAACTCAAGAGCAGCTGCAATGGATATACGATGAAGAGACCGATTGCATGATTGAAAAAAATGTCACAATTGTACCAGGGTTGTTCAAAATCTTTGATGAAATCTTAGTCAATGCGGCAGATAATAAAGTTCGTGATCCATCGATGAAACGAATCGATGTAAACATACATGCTGAGGAACATACTATAGAAGTGAAAAATGATGGAAAAGGTATTCCCATAGAGATTCATAACAAGGAGAATATTTATATTCCTGAAATGATATTTGGTCATTTGTTGACATCATCCAATTATGATGATGATGAGAAGAAAGTCACTGGTGGTAGAAACGGTTATGGTGCTAAGCTTTGTAATATATTTTCCACTGAATTCATATTAGAAACTGCAGATCTAAATGTTGGCCAGAAATATGTTCAAAAATGGGAAAATAACATGAGCATTTGCCACCCCCCAAAAATAACATCTTACAAGAAGGGTCCATCATATACAAAGGTGACATTTAAGCCGGATTTAACCAGATTCGGAATGAAAGAGCTAGATAATGATATCTTAGGAGTGATGCGAAGAAGAGTTTATGATATCAATGGTTCTGTTCGTGACATTAATGTCTATCTGAATGGCAAGTCCTTAAAGATAAGAAATTTCAAAAATTATGTTGAACTCTACTTGAAATCACTCGAAAAAAAAAGACAACTAGATAACGGTGAGGACGGTGCCGCTAAGTCTGATATCCCGACTATTCTTTATGAGAGAATAAACAACAGATGGGAAGTTGCTTTTGCGGTTTCTGATATCTCTTTTCAACAAATTTCTTTTGTGAATTCCATTGCAACTACCATGGGTGGTACCCATGTCAATTACATAACAGACCAAATTGTAAAAAAAATTTCAGAAATTTTGAAGAAAAAGAAGAAAAAAAGTGTGAAGTCTTTTCAGATTAAAAATAATATGTTCATTTTCATTAATTGTTTGATTGAGAATCCTGCATTTACCTCACAAACAAAAGAGCAACTGACAACAAGAGTCAAAGATTTTGGGTCCCGTTGTGAGATTCCTCTTGAATATATTAATAAGATTATGAAAACTGATTTGGCTACAAGAATGTTTGAAATTGCCGACGCAAATGAAGAAAATGCGCTAAAGAAGTCTGATGGTACAAGGAAAAGCAGAATTACTAATTACCCTAAACTGGAAGATGCCAACAAAGCCGGTACAAAAGAAGGCTATAAATGTACTTTAGTTCTGACAGAAGGGGATTCCGCCTTGTCATTAGCTGTTGCAGGTTTAGCTGTTGTTGGTAGAGATTATTATGGTTGTTATCCACTTCGTGGTAAAATGCTGAATGTTAGAGAAGCTAGTGCTGATCAGATACTAAAAAACGCGGAAATTCAAGCCATTAAAAAAATTATGGGGTTACAACATCGCAAGAAATATGAAGATACAAAATCTTTAAGATATGGGCATCTTATGATCATGACCGATCAAGATCATGATGGTTCGCATATTAAAGGTTTAATTATAAACTTTTTAGAAAGCTCATTTCCTGGTCTTTTGGATATCCAAGGTTTCTTACTTGAATTCATAACTCCGATCATCAAAGTTTCCATCACTAAACCAACAAAAAACACTATTGCATTCTACAATATGCCGGACTATGAAAAATGGAGAGAGGAAGAATCGCACAAATTTACTTGGAAGCAGAAGTATTATAAAGGATTAGGGACTTCTCTAGCACAAGAAGTCCGAGAATATTTTTCGAACTTGGACAGACATTTGAAAATATTCCATTCTTTGCAGGGTAATGATAAAGATTACATTGATTTAGCTTTCTCCAAGAAAAAGGCAGATGACCGTAAAGAATGGCTGAGACAATACGAACCTGGTACTGTTTTAGACCCTACTTTAAAAGAGATTCCAATTAGCGACTTCATTAATAAGGAATTAATCCTTTTTTCTTTGGCCGATAATATACGGTCGATTCCCAATGTTTTAGATGGATTTAAACCTGGCCAAAGAAAAGTTCTTTATGGTTGTTTCAAAAAAAATTTAAAGTCGGAACTGAAAGTAGCTCAACTTGCACCATACGTGAGCGAATGTACGGCATATCACCATGGTGAGCAGTCATTGGCACAAACTATTATTGGGCTAGCCCAAAACTTTGTTGGGTCCAACAATATTTACTTGCTATTACCTAACGGTGCTTTCGGTACAAGAGCCACTGGTGGTAAAGATGCAGCGGCAGCGAGATATATCTACACAGAATTGAACAAATTAACTCGTAAGATATTTCACCCTGCTGATGATCCATTATACAAATATATACAAGAAGATGAGAAAACAGTGGAGCCAGAGTGGTATTTACCAATTCTTCCTATGATTCTTGTTAACGGTGCTGAGGGTATTGGCACTGGCTGGAGTACTTACATTCCTCCATTCAACCCATTGGAAATTATAAAGAATATAAGACATTTAATGAACGACGAGGAGCTTGAGCAAATGCATCCGTGGTTTAGGGGATGGACCGGTACTATTGAAGAAATTGAGCCTCTGCGTTACAGAATGTACGGTAGGATTGAACAAATTGGAGATAACGTCTTAGAAATAACTGAGTTGCCAGCCAGAACTTGGACATCGACTATAAAGGAGTACTTACTTTTAGGTTTAAGCGGTAACGATAAAATAAAACCCTGGATCAAAGATATGGAGGAGCAGCACGATGATAACATCAAATTCATAATCACGCTATCACCTGAGGAAATGGCTAAAACAAGGAAAATAGGTTTTTATGAAAGATTTAAACTAATTTCGCCTATAAGTTTGATGAATATGGTCGCATTTGATCCTCACGGGAAAATCAAGAAGTACAATTCCGTGAATGAAATATTAAGCGAATTTTACTACGTCAGACTAGAATACTATCAAAAAAGAAAAGACCATATGAGCGAAAGGTTACAGTGGGAGGTAGAGAAATACTCTTTCCAAGTAAAATTTATTAAAATGATTATTGAAAAGGAGTTAACAGTCACCAATAAGCCTAGGAACGCTATTATCCAAGAACTTGAGAATTTAGGGTTCCCCAGATTTAATAAGGAAGGTAAACCATATTATGGAAGTCCTAACGATGAGATAGCTGAACAAATTAACGACGTAAAAGGCGCAACTTCTGATGAAGAAGATGAAGAAAGTTCACACGAAGATACTGAAAATGTTATAAATGGTCCTGAAGAACTATATGGCACATATGAATATTTATTAGGAATGAGAATATGGTCATTGACCAAGGAAAGATATCAAAAGCTGTTGAAACAAAAACAAGAAAAGGAGACAGAGTTGGAAAACTTGTTAAAACTTTCCGCGAAAGATATATGGAACACTGACTTGAAGGCTTTTGAGGTGGGATATCAAGAATTTTTGCAACGAGATGCAGAAGCTCGCGGTGGTAATGTTCCCAATAAAGGGAGCAAAACGAAAGGTAAAGGAAAAAGAAAGCTTGTTGACGACGAAGACTACGACCCATCAAAAAAAAACAAGAAAAGTACTGCTAGAAAGGGCAAAAAAATTAAGTTAGAGGATAAGAATTTTGAAAGGATTTTGTTAGAACAAAAACTAGTAACCAAAAGCAAGGCGCCTACAAAGATTAAAAAAGAGAAAACGCCTTCTGTTTCAGAAACAAAAACAGAAGAAGAAGAGAATGCTCCTTCTTCCACGAGTTCTTCTTCTATTTTCGACATAAAGAAAGAAGATAAAGATGAGGGCGAACTGAGTAAGATTTCGAACAAGTTTAAAAAAATTAGCACGATTTTTGACAAAATGGGTTCTACTTCCGCTACATCGAAGGAAAATACACCAGAACAGGACGATGTAGCCACTAAAAAAAATCAAACAACCGCTAAAAAAACAGCTGTAAAACCTAAATTGGCCAAGAAGCCAGTCAGGAAACAACAAAAAGTTGTGGAACTATCTGGTGAAAGCGACCTAGAAATTTTAGATTCATACACTGATCGGGAAGATAGCAATAAAGATGAAGATGATGCTATACCACAACGATCAAGGAGACAAAGATCGTCGAGAGCTGCGTCGGTTCCTAAGAAATCTTACGTTGAAACTTTAGAATTATCTGACGACAGTTTCATCGAAGATGATGAAGAGGAAAACCAAGGATCAGATGTTTCGTTCAATGAAGAGGATTGA | |
| Amino acid sequence: | Length=1428bp |
| BlastP NCBI nr
MSTEPVSASDKYQKISQLEHILKRPDTYIGSVETQEQLQWIYDEETDCMIEKNVTIVPGLFKIFDEILVNAADNKVRDPSMKRIDVNIHAEEHTIEVKNDGKGIPIEIHNKENIYIPEMIFGHLLTSSNYDDDEKKVTGGRNGYGAKLCNIFSTEFILETADLNVGQKYVQKWENNMSICHPPKITSYKKGPSYTKVTFKPDLTRFGMKELDNDILGVMRRRVYDINGSVRDINVYLNGKSLKIRNFKNYVELYLKSLEKKRQLDNGEDGAAKSDIPTILYERINNRWEVAFAVSDISFQQISFVNSIATTMGGTHVNYITDQIVKKISEILKKKKKKSVKSFQIKNNMFIFINCLIENPAFTSQTKEQLTTRVKDFGSRCEIPLEYINKIMKTDLATRMFEIADANEENALKKSDGTRKSRITNYPKLEDANKAGTKEGYKCTLVLTEGDSALSLAVAGLAVVGRDYYGCYPLRGKMLNVREASADQILKNAEIQAIKKIMGLQHRKKYEDTKSLRYGHLMIMTDQDHDGSHIKGLIINFLESSFPGLLDIQGFLLEFITPIIKVSITKPTKNTIAFYNMPDYEKWREEESHKFTWKQKYYKGLGTSLAQEVREYFSNLDRHLKIFHSLQGNDKDYIDLAFSKKKADDRKEWLRQYEPGTVLDPTLKEIPISDFINKELILFSLADNIRSIPNVLDGFKPGQRKVLYGCFKKNLKSELKVAQLAPYVSECTAYHHGEQSLAQTIIGLAQNFVGSNNIYLLLPNGAFGTRATGGKDAAAARYIYTELNKLTRKIFHPADDPLYKYIQEDEKTVEPEWYLPILPMILVNGAEGIGTGWSTYIPPFNPLEIIKNIRHLMNDEELEQMHPWFRGWTGTIEEIEPLRYRMYGRIEQIGDNVLEITELPARTWTSTIKEYLLLGLSGNDKIKPWIKDMEEQHDDNIKFIITLSPEEMAKTRKIGFYERFKLISPISLMNMVAFDPHGKIKKYNSVNEILSEFYYVRLEYYQKRKDHMSERLQWEVEKYSFQVKFIKMIIEKELTVTNKPRNAIIQELENLGFPRFNKEGKPYYGSPNDEIAEQINDVKGATSDEEDEESSHEDTENVINGPEELYGTYEYLLGMRIWSLTKERYQKLLKQKQEKETELENLLKLSAKDIWNTDLKAFEVGYQEFLQRDAEARGGNVPNKGSKTKGKGKRKLVDDEDYDPSKKNKKSTARKGKKIKLEDKNFERILLEQKLVTKSKAPTKIKKEKTPSVSETKTEEEENAPSSTSSSSIFDIKKEDKDEGELSKISNKFKKISTIFDKMGSTSATSKENTPEQDDVATKKNQTTAKKTAVKPKLAKKPVRKQQKVVELSGESDLEILDSYTDREDSNKDEDDAIPQRSRRQRSSRAASVPKKSYVETLELSDDSFIEDDEEENQGSDVSFNEED | |