GMMAD2: Gut Microbial Metabolite Association with Disease

The natural products, metabolites, of gut microbes are the crucial effect factors on diseases. Comprehensive identification and annotation of relationship among diseases, microbes and metabolites can provide accurate and targeted solutions towards understanding the mechanism of complex disease and development of new markers and drugs.

To help researchers better understand the mechanisms of metabolite regulation and find potential new drugs, we built the GMMAD2 (Gut Microbial Metabolite Association with Disease, http://gepa.org.cn/GMMAD2) which aims to provide users comprehensive metabolite related information of gut microbes in human diseases.

Compared to the GMMAD version 1.0, the GMMAD2 database quantitatively measures disease-metabolite association based on microbial abundance levels, with a prediction accuracy of 84.06%. In addition, we supplement the interaction relationship between microbial metabolites and host genes.

Currently, GMMAD2 is free to access, browse, search, and download.

Members: Guo Lab

Address: School of Pharmaceutical Sciences, Wuhan University, China.

Mail: fbguoy@whu.edu.cn

• Disease-Metabolite 175786
• Microbe-Metabolite 873576
• Disease-Microbe 508141
• Metabolite-Gene 53823
• Diseases 83
• Metabolite 2944
• Microbe 6966
• Gene 8247

• April. 20, 2025

  Data update

  Added literature cases on metabolite intervention in diseases.

• March. 01, 2025

  Feature Optimization Update

  Replaced html2canvas with Cytoscape.js native export to significantly improve image resolution and clarity.

• February. 23, 2025

  Data update

  The metabolite-gene module has been updated based on the content from the DrugBank database.

• July. 4, 2024

  Data update

  Added drug target interaction information in the drugbank database and merged genes with duplicate IDs.

• December. 18, 2023

  GMMAD 2.0

  The GMMAD v2.0 was released.

• February. 12, 2022

  GMMAD 1.0

  The GMMAD v1.0 was released.